Common plant fiber gel doubled rate of tumor eradication

Many people don’t realize that the trillions of bacteria, viruses, and fungi residing within the gastrointestinal tract—collectively called the gut microbiome—are connected to overall health, and specifically to cancer.

Manipulating the gut microbiome to produce ‘beneficial’ commensal microbes, which protect the host from pathogens and can boost immune responses, among other things, could potentially help patients respond better to cancer drugs called immune checkpoint inhibitors, a type of immunotherapy.

To that end, researchers at the University of Michigan have developed a new dietary fiber formulation that improves the potency of immunotherapies against cancer by modulating the gut microbiome. In the future, cancer patients treated with immune checkpoint blockers may benefit from consuming this inulin gel dietary fiber, said James Moon, the John G. Searle Associate Professor of Pharmaceutical Sciences in the College of Pharmacy. The findings appear in the June 24 issue Nature Biomedical Engineering.

Inulin, a dietary fiber found in chicory root, Jerusalem artichoke and other plants, is a prebiotic that helps produce colon-residing commensal bacteria. By formulating inulin into a more colon-targeted inulin gel formulation, the team was able to provide a rich source of nutrients to allow beneficial gut microbes to expand more in the gastrointestinal tract.

The inulin gel improved immune checkpoint inhibitor therapy in rodents with colon carcinoma as well as melanoma. For instance, when inulin gel was combined with an immune checkpoint inhibitor in a colon carcinoma rodent model, the rate of tumor eradication doubled (100% improvement), compared with the immune checkpoint inhibitor therapy alone.

“Consumption of the inulin gel expanded and increased the number of beneficial microbes in tumor-bearing mice,” said Kai Han, postdoctoral fellow and first author of the study. “These are beneficial commensal microbes that are found in cancer patients who respond well to immune checkpoint inhibitors.”

“The current approaches to restoring a healthy gut microbiome include oral ingestion of defined probiotics or fecal microbiota transplantation,” Han said. “However, it would be very challenging to develop these as pharmaceutical products due to scale-up manufacturing and quality control.”

The human microbiome has recently emerged as the next frontier in drug development. Intense research interest in the microbiome is driven by evidence linking the potential health benefits of modulating gut microbiota to treating various diseases, including cancer, diabetes, obesity and neurodegenerative diseases. In particular, a series of recent studies showed that the gut microbiome plays a crucial role in cancer patients’ response rate to immune checkpoint inhibitors, Moon said.

“We and others have shown that the gut microbiome has a crucial role in our immune responses,” Han said. “Close to 70% of lymph nodes in our bodies are located in the gastrointestinal tract and therefore, microbes residing in the gastrointestinal tract closely interact with our immune cells. Maintaining a healthy gut microbiome nurtures our immune system so that our immune cells can effectively fight against cancer.”

The group chose inulin because it wanted something that could be readily translated to the clinic. Inulin is a dietary fiber that is widely consumed by the public and is present in many plants. It’s used as a sugar substitute and in candies and butter. By making inulin into inulin gel, researchers found that inulin gel coats the gastrointestinal tract much better, leaving more nutrients to the commensal microbes.

The inulin gel also works with anti-PD-1 plus anti-CTLA-4 combo-therapy, (widely used immune checkpoint inhibitors) that treat many types of cancer, Han said.

Roughly 10-30% of cancer patients respond to immune checkpoint inhibitors, depending on the types of cancer, and there is risk of serious immune-related complications and side-effects, Moon said. For instance, inflammation in the gastrointestinal tract and skin are common. Previous studies have shown that inulin consumption may alleviate gastrointestinal inflammation, such as colitis and IBD.

“So, inulin gel may alleviate gastrointestinal inflammation induced by immune checkpoint inhibitors and we are testing this idea now,” Moon said.

“Generation of systemic anti-tumor immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel”

12,541 thoughts on “Common plant fiber gel doubled rate of tumor eradication

  1. Hello,

    Download Music FLAC Private Server: https://0daymusic.org/premium.php
    Genre: House, Club, Techno, Trance, Dance, Italo-Dance, Eurodance, Drum and Bass, Psychedelic, Goa, PsyTrance, Progressive House, Electro, Euro-House, Club-House, Hardtechno, Tech-House, Dutch House, Minimal, Deep-House, Nu-Disco, Hardstyle, Hardcore, Jumpstyle, Electronic, Alternative, Alternative Rock, Ambient, Avantgarde, Ballad, Bass, Beat, Black Metal,Blues, Classical, Chanson, Country, Dance Hall, Death Metal, Disco, Ethnic, Folk, Folk-Rock, Funk, Gangsta Rap, Gothic Rock,Hard Rock, Heavy Metal, Hip-Hop, Indie, Industrial, Instrumental, Jazz, Jungle, Pop, Rock, Metal, Latin, Lo-Fi, New Age, Noise, Oldies, Pop-Folk, Progressive Rock, Psychedelic Rock, Punk Rock, Rap, Reggae, R&B, Rock & Roll, Soul, Soundtrack, Speech, Synthpop, Thrash Metal, Top 40, Vocal etc.

    Best regards, Charles

  2. Здравствуйте. Помогу вам решить проблемы с вашим сайтом. Сделаю его более посещаемым, приносящим вам значительно больший доход. Я успешно занимаюсь сайтами больше семнадцати лет. Работаю качественно, цены небольшие, гарантии результата.

    Основные области моей деятельности:

    1. Продвижение сайтов в поисковых системах. Помогу вывести ваш сайт на первые места по представляющим для вас интерес запросам.

    2. Внутренняя оптимизация и решение всех проблем с сайтом. Помогу сделать ваш сайт максимально качественным и соответствующим требованиям поисковых систем. Решу все проблемы (от кода и до дизайна).

    3. Создание сайтов. Занимаюсь созданием сайтов различных типов.

    4. Создание и продвижение групп и каналов в социальных сетях (ютуб, вк, фейсбук и т. д.).

    5. Работа с отзывами. Создание и продвижение хороших отзывов в интернете, удаление и уменьшение видимости плохих.

    6. Существует и многое иное в чем я мог бы вам оказаться полезным. Работаю как с коммерческими, так и с информационными проектами.

    Если вас заинтересовало, то пишите на следующий адрес: [email protected]

  3. Здравствуйте. Помогу решить проблемы с вашим сайтом. С моей помощью ваш сайт может стать значительно более посещаемым и приносящим больший доход. Умею привлекать на сайт целевых посетителей и повышать конверсию. Занимаюсь созданием, доработкой и продвижением сайтов с 2004 года. Работаю как с коммерческими, так и с информационными проектами. Умеренные расценки.

    Занимаюсь я следующим:

    1. Продвижение сайтов в поисковых системах. Помогу вывести ваш сайт на первые места по представляющим для вас интерес запросам.

    2. Исправление ошибок и доработка сайтов. Помогу сделать ваш сайт максимально качественным и соответствующим требованиям поисковых систем. Работаю над выявлением и устранением ошибок, повышением конверсии, ускорении загрузки сайта и т. п. Занимаюсь самыми различными вопросами, от кода и до дизайна.

    3. Создание сайтов. Занимаюсь созданием сайтов различных типов.

    4. Создание, наполнение и продвижение групп и каналов в социальных сетях (youtube, вконтакт, фейсбук и т. д.).

    5. Работа с отзывами. Создание и продвижение хороших отзывов в интернете, удаление и уменьшение видимости плохих.

    6. Различные виды рассылок по выборке из моих баз данных под ваш бизнес. Занимаюсь следующими рассылками: e-mail рассылки, рассылки по формам обратной связи, рассылки по чатам на сайтах, рассылки по профилям социальных сетей.

    7. Существует и многое иное в чем я мог бы вам оказаться полезным.

    Для связи со мной пишите на эту почту: [email protected]

  4. Sеlf-Imрrovement and success go hаnd in hand. Taking thе stерs tо make уоursеlf а better and mоrе well-roundеd individuаl will рrоvе to bе а wise decisiоn. https://thoughtoftheday.btcfreedom.design
    The wisе рerson fеels thе pain of оne arrоw. Thе unwisе feеls thе pаin of twо.
    Whеn lооking fоr wise wоrds, the best ones оften come from оur еldеrs.
    You’vе heard thаt it’s wisе to leаrn from exрeriencе, but it is wisеr tо lеarn frоm the еxpеrience оf othеrs.
    We tеnd tо think оf great thinkers аnd innovаtоrs аs soloists, but thе truth is that the greаtеst innоvаtivе thinking dоesn’t оccur in a vаcuum. Innovаtiоn rеsults frоm collabоration.
    Sоmе of us think holding оn mаkes us strоng, but somеtimes it is lеtting go.
    But whаt I’vе discоverеd оvеr time is thаt somе оf the wisest peoplе I know hаve аlsо been sоmе of thе mоst broken pеорle.
    Dоn’t waste your timе with explаnations, реоplе onlу heаr what theу want to hеar.
    Tо makе difficult dеcisiоns wisеly, it helps tо havе a systеmаtic рrоcess for аssessing eаch choice аnd its cоnsequencеs – the pоtential impact on eаch аsрect of yоur life.
    Each of us еxреriences defeats in life. Wе cаn transfоrm dеfeat into victоrу if wе lеarn frоm lifе’s whupрings.

  5. Ηellо аll, guysǃ I knоw, my mеssаgе mау bе too ѕрeсifiс,
    Βut my ѕіster found nісе mаn hеrе and they married, sо how about mе?ǃ 🙂
    I аm 27 уearѕ old, Iѕаbella, frоm Ukrаine, I knоw Еnglish аnd Gеrman lаnguages аlsо
    Αnd… Ι havе ѕpесifіс dіѕeaѕе, named nуmрhomаnіa. Ԝhо know what іs thіs, can undеrstand mе (better to sаy іt іmmediаtelу)
    Ah yes, Ι cооk vеry tаstуǃ аnd Ι love nоt only соok ;))
    Im real gіrl, nоt prоstitute, аnd loоking fоr ѕeriouѕ and hot relatiоnѕhiр…
    Аnуwау, уou cаn fіnd mу prоfile here: http://peotracsusetiti.gq/user/2537/

  6. Wow, amazing blog layout! How long have you been running a blog for? you make blogging look easy. The overall glance of your site is great, as well as the content!good job guys.

  7. Well I truly liked studying it. This information procured by you is very helpful for correct planning.please click my name above and try to visit guys~

  8. https://www.vykupspb.ru/ – Срочный выкуп битых автомобилей марки Metrocab модели TTS, 1908 года выпуска, тип кузова внедорожник открытый с объемом двигателя 2692 коробка передач механическая в Петербурге.

  9. Howdy terrific website! Does running a blog like this require a massive amount work?
    I’ve virtually no expertise in coding however I was hoping to start my own blog soon. Anyway, should you have any recommendations or techniques for new blog owners please share.
    I understand this is off topic however I just had to ask.
    Thanks a lot!